Impact of glucose level on micro and macrovascular. View the article pdf and any associated supplements and figures for a period of 48 hours. All participants answered similar questionnaires, which. We included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a population based prospective cohort study initiated in april 2014 with ongoing enrolment. Obesity as a causal risk factor for aortic valve stenosis. The copenhagen general population study documented that in a general population context among individuals with copd, blood eosinophil levels above 340 cells. We prospectively followed 108 521 individuals from the copenhagen general population study for a median of 8 years. We identified and ranked chronic cough risk factors at the individual and community level using data from 14,669 individuals from the copenhagen general population study. Furthermore, our study indicates the need for a multifaceted. Jul 29, 20 we included individuals from the copenhagen general population study, a prospective population study.
Genetically low vitamin d concentrations and increased. Risk factors for chronic cough among 14,669 individuals from. The cchs provided the general population sample from denmark. The copenhagen general population study the primary study cohort was comprised of 97 166 individuals from the prospective copenhagen general population study with baseline measurements of hdl cholesterol. Outcomes consequent to early copd for interventional studies. The copenhagen general population study cgps is an ongoing prospective cohort study of the danish general population. The copenhagen city heart study, bispebjerg and frederiksberg hospital, copenhagen, denmark. It was initiated in 2003 and recruitment is ongoing.
Participants were selected randomly from the national civil registration system to represent the danish population aged 20100 years. The highdensity lipoproteinadjusted score model worsens. A random general population sample of 210 children from the copenhagen child birth cohort ccc 2000 was investigated by data from national danish registers and data collected prospectively from. The copenhagen general population study, herlev and gentofte hospital, copenhagen university hospitals, copenhagen, denmark. Methods study design and participants we included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a population based prospective cohort study initiated in april 2014 with ongoing enrolment. Seroepidemiology of pertussis in a crosssectional study. Hospital10 the copenhagen general population study, herlev hospital. We included individuals from the copenhagen general population study, a prospective population study. The table to the right includes counts of all research outputs for the copenhagen general population study published between 1 december 2018 30 november 2019 which are tracked by the nature index. The two sister studies in the copenhagen area include the copenhagen city heart study and. The first 5592 included copenhagen general population study participants had lipoproteina total mass measured using a sensitive immunoturbidimetric assay from diasys diasys, diagnostic systems, holzheim, germany and the following participants in the copenhagen general population.
Among 81,668 individuals in the copenhagen general population study, we examined 7,225 with copd based on spirometry. Krogfelt1 1department of microbiology and infection control, statens serum institut, copenhagen denmark 2epidemiology research, statens serum institut, copenhagen denmark 3department of microbiology. Impact of glucose level on micro and macrovascular disease. In this prospective cohort study, we analysed data from 95 288 individuals aged 20100 years from the copenhagen general population study. Major longlasting european studies of the general population this. Risk factors for chronic cough in the general population have not been described systematically. Patients and methods we examined 86,975 individuals from the copenhagen general population study, recruited from 2003 through 2010. A mendelian randomisation design was used with data. Dec 15, 2016 the copenhagen city heart study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. Participants completed a selfadministered questionnaire concerning. The copenhagen general population study cgps is a danish contemporary population based cohort study initiated in 2003 with ongoing enrollment. Problems of feeding, sleeping and excessive crying in infancy. We observed that individuals with chronic respiratory symptoms and normal spirometry had an increased risk of hospitalisations and death due to respiratory disease 1.
In the copenhagen general population study, with 81,668 individuals, the corresponding value was 63 %. Increasedriskforothercancersinadditiontobreastcancer for. Copenhagen general population study the british journal of. Epidemiological studies of mental health problems in the first years of life are few. Cgps abbreviation stands for copenhagen general population study.
Lipoproteina and ischemic heart disease a causal association. Combined effect of pnpla3, tm6sf2, and hsd17b variants. Obese individuals experience wheezing without asthma but not asthma without wheezing. Remnant cholesterol and myocardial infarction in normal weight, overweight, and obese individuals from. Oct 09, 2015 the copenhagen city heart study, also known as osterbroundersogelsen, is a large prospective cardiovascular population study of 20,000 women and men that was launched in 1975 by dr peter schnohr and dr gorm jensen together with statistician jorgen nyboe and prof. The participants completed a questionnaire before attending a physical examination including collection of whole blood for dna. Eligibility and preventive potential for new evidence. Obese individuals experience wheezing without asthma but not.
The current study population consisted of participants in a large population based study, inter99, which is reported in detail elsewhere 25, 39, 40. Prevalence, characteristics, and prognosis of early. In the present study, we compared the clinical performance of these two risk assessment models and evaluated the incremental predictive value of hdl cholesterol in an independent and contemporary european population, the copenhagen general population study cgps. Prevalence, characteristics, and prognosis of early chronic obstructive pulmonary disease. The initial sample has been reinvited up to four times and supplemented by younger individuals. Copenhagen university hospital, clinical biochemistry, herlev, denmark. We tested the hypothesis that high tobacco consumption is causally associated with low body weight. Copenhagen general population study 2003 to 2006 examination and copenhagen city heart study 2001 to 2003 examination7 recruited participants randomly from the general population of copenhagen, denmark. Exploring causal associations between alcohol and coronary.
Wheezing was selfreported, and asthma was ascertained through selfreport, hospital contacts with. In the copenhagen general population study, the jak2 v617f mutation was detected by a pcrbased taqman screening assay identifying the 1% with the highest signal, these were subsequently tested with a highly sensitive realtime qpcr assay with a limit of detection of 0. Major longlasting european studies of the general population this online supplement includes short summaries of largescale studies of the general population on the epidemiology of respiratory diseases and allergy that have been in progress for about 30 years or more and are still active. Objective to study regulatory problems rps of feeding, sleeping and excessive crying in infancy, and explore the influence of maternal mental health problems and parentchild relationship problems. This study aims to investigate infancy predictors of psychopathology in the second year of life. We recruited 94 079 individuals aged 20100 years from the copenhagen general population study, a prospective populationbased cohort study initiated in 2003 with ongoing enrolment. In this questionnaire we will ask you to answer some questions about your health and lifestyle.
We identified individuals with copd spirometrically. General population study cgps 20032007 exami nation 7 and the copenhagen city heart study. Participants 95 766 white participants of danish descent from three cohorts, with median followup times. The first crosssectional survey on the general population sample of urban and suburban residents of pisa pi1 was performed in 19851988. Accaha guidelines superior to esceas guidelines for. The copenhagen general population study atherosclerosis.
Below, the same research outputs are grouped by subject. Future longitudinal studies should focus on possible risk factors for airflow limitation in this population. Comparison of major guidelines for statin use in primary. Prevalence, characteristics, and prognosis of early chronic. In the second examination, individuals are invited from the same. Healthy lifestyles reduce supar and mortality in a danish. Coronary artery calcium assessed with calibrated mass. Jan 16, 2018 observational study of actual ascvd events during 10 years, followed by a modeling study to estimate the effectiveness of different guidelines. Nordestgaard 2,3,4, marianne benn 2,3,4, luisa zuccolo 1, anne tybjaerghansen 2,3,5, and george davey smith 1. Danish population study offers opportunity for discovery of blood biomarkers in individuals who suffer a heart attack without prior history of cardiovascular disease. Methods participants from the copenhagen general population study underwent multidetector computed tomography. The copenhagen city heart study is a prospective cardiovascular study of the danish general population initiated in 1976.
Seroepidemiology of pertussis in a crosssectional study of an adult general population in denmark p. Characteristics and outcomes of chronic obstructive. New findings from an analysis of 98,097 subjects from the copenhagen city heart study and the copenhagen general population study link lpa with risk for heart failure. Mar 19, 2020 the copenhagen general population study, herlev and gentofte hospital, herlev, denmark.
The cgps is an ongoing prospective cohort study of the danish general population. Participation rates in general population studies in europe vary from 10% 15 to. The authors thank the staff and participants of the copenhagen general population study and the copenhagen city heart study, and the participants of the metaanalyses of glucose and insulinrelated traits consortium magic, the ckdgen consortium, the uk biobank, and the cardiogramplusc4d consortium for their generous participation. The copenhagen city heart study osterbroundersogelsen. Design, setting, and participants this population based contemporary cohort study included 6292 patients with known ischemic heart disease ihd and 2277 with a previous myocardial infarction mi enrolled between november 2003 and february 2015. Methods the study included 49,699 individuals from the copenhagen general population study and 10,8 individuals from the copenhagen city heart study with measurements of plasma lipoproteina, lpa kringleiv type 2 number of repeats, and lpa rs10455872. Majority of neversmokers with airflow limitation do not. Ushapedrelationshipofhdlandrisk ofinfectiousdisease. The copenhagen city heart study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. Study design, participation and characteristics of the. Faculty of health and medical sciences, university of copenhagen, copenhagen, denmark. Pdf predictors 010 months of psychopathology at age. Methods we genotyped 85 437 individuals aged 20100 years from the copenhagen general population study for fto rs9939609, mc4r rs177823, tmem18 rs6548238 gnpda2 rs10938397 and bdnf rs10767664. News from the european atherosclerosis society congress.
Conflicting evidence has been found regarding the association between high tobacco consumption and body weight among smokers. We studied participants in the copenhagen general population study, an ongoing cohort study initiated in 2003. Blood eosinophils and exacerbations in chronic obstructive. A total of 58527 individuals from the cgps had baseline measurements of lpa. Nonfasting triglycerides and risk of myocardial infarction. Combined effect of pnpla3, tm6sf2, and hsd17b variants on. High risk of fatty liver disease amplifies the alanine. The relationship between volumetric thoracic bone mineral.
The participants completed a questionnaire on health and lifestyle, were examined physically, had blood drawn for dna extraction, were tested for presence of chek21100delc using. Setting copenhagen city heart study, copenhagen general population study, and copenhagen ischemic heart disease study. Obese individuals experience wheezing without asthma but. Bg medicine today announced that it has entered into a research collaboration agreement with the copenhagen general population study with the goals to discover and validate novel cardiovascular biomarkers, including those. What is the abbreviation for copenhagen general population study. The copenhagen general population study is supported by the copenhagen county foundation and herlev and gentofte hospital, copenhagen university hospital, denmark. Icosapent ethyl for the prevention of cardiovascular events. Genomewide association and transcriptome studies identify target genes.
The copenhagen general population study was initiated in 2003 with ongoing enrollment. Increased risk for other cancers in addition to breast cancer. Total mortality by transferrin saturation levels oxford academic. Majority of neversmokers with airflow limitation do not have. But perhaps, a headtohead comparison of remnant cholesterol with ldl cholesterol can be reported on in a followup publication, similar to what we have reported previously for individuals in the general population 15 and in patients with ischemic heart disease. The copenhagen general population study herlevosterbroundersogelsen 2008.
We tested the hypothesis that high plasma glucose caused by genetic variation has a causal effect on the risk of unspecified dementia, alzheimers disease and vascular dementia in the general population. The copenhagen general population study, denmark institution. The copenhagen general population study abstract send to citation mgr. The copenhagen city heart study is a prospective study of the copenhagen general population initiated in 1976.
In the eclipse evaluation of copd longitudinally to identify predictive surrogate endpoints study cohort, only 37% of the patients with copd had persistently increased blood eosinophils at or above 2%. Major longlasting european studies of the general population. The population was grouped according to number of traditional risk factors and heart score was used to assess the risk of event for those with no cac, those with only cms 0 and those with both as and cms 0. Briefly, 61,301 individuals from a general population, aged 30 to 60 years and living in the southwestern part of copenhagen were randomly selected to participate in the study. Furthermore, diseasefree participants of the copenhagen general population study are very well suited to act as controls in casecontrol studies, where other research groups can provide cases. Combined value of exhaled nitric oxide and blood eosinophils. Arterial and venous thrombosis by high platelet count and.
Prognosis of asymptomatic and symptomatic, undiagnosed copd. The advantage of this approach in contrast to nested casecontrol studies is that the copenhagen general population study will contain an ever increasing amount of information on all participants allowing for detailed studies of risk factor interactions and in substrata of the general population. Pdf the copenhagen city heart study osterbroundersogelsen. The copenhagen city heart study, also known as osterbroundersogelsen, is a large prospective cardiovascular population study of 20,000 women and men that was launched in 1975 by dr peter schnohr and dr gorm jensen together with statistician jorgen nyboe and prof. Nov 18, 2014 objective to test the hypothesis that genetically low 25hydroxyvitamin d concentrations are associated with increased mortality. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Rennard was particularly interested in estimating the sample size required for an intervention trial in individuals with early copd based on the outcomes used in our. We tested the hypothesis that individuals from the general population with high platelet count or high hematocrit have high risk of arterial and venous thrombosis. Leukotriene c4 synthase and risk of cardiovascular.
Increased risk for other cancers in addition to breast. Characteristics and outcomes of chronic obstructive pulmonary. A random general population sample of 210 children from the copenhagen child birth cohort ccc 2000 was investigated by data from national danish registers and data collected prospectively from birth in a general child health surveillance programme. Fh initiative headlining the congress was the launch of the eas familial hypercholesterolaemia studies collaboration fhsc, a consortium of major fh registries across europe, asiapacific, africa and south america, led by professor kausik ray imperial college, london.
The copenhagen general population study n 56 960 is a prospective study initiated in 2003,20 and the copenhagen city heart study n 9041 is a prospective study initiated in 1976. Mendelian randomisation studies have not shown a clear causal effect of high plasma glucose on the risk of alzheimers disease. The copenhagen general population study, herlev and gentofte hospital, herlev, denmark. Analyses were performed in the copenhagen general population study with a mean sd of 7. Remnant cholesterol and triglyceriderich lipoproteins in. We recorded blood eosinophils at baseline and future copd exacerbations longitudinally, defined as moderate shortcourse treatment with systemic corticosteroids or severe hospitalization. New analysis from copenhagen general population study reaffirms. Original article majority of neversmokers with air. Jan 22, 2019 the current study population consisted of participants in a large population based study, inter99, which is reported in detail elsewhere 25, 39, 40. Design and setting data were collected in the general child health surveillance delivered to infant families by community health nurses chns. The study includes questionnaires, clinical assessment and biomarkers. All individuals in denmark are assigned a unique identification number at birthimmigration that is recorded in the national danish civil registration system. Risk of venous thromboembolism and myocardial infarction.
The aim of this study was to assess the potential relationship between volumetric thoracic bone mineral density and coronary calcification in a large population of men and women. Methods study design and participants we included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a populationbased prospective cohort study initiated in april 2014 with ongoing enrolment. Bg medicine and copenhagen general population study. Participants n 2985 from the copenhagen general population study were evaluated for cac using both conventional as and cms. In this study the population sample was also a stratified, family cluster design. The highdensity lipoproteinadjusted score model worsens scorebased risk classification in a contemporary population of 30,824. In the present study we pooled data from two similar but independent studies. Among 81,668 individuals from the copenhagen general population study, we examined 7,225 with copd based on spirometry. Elevated lipoproteina and risk of ischemic stroke jacc. Platelet count and blood hematocrit were measured at. Hover over the donut graph to view the fc output for each subject.
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